This article showcases Startup Pill’s top picks for the best Therapeutics startups. These startups are taking a variety of approaches to innovating inside of the Therapeutics industry and around the world. They are all exceptional startups well worth a follow.
We tried to pick companies across the size spectrum from cutting edge startups to established brands.
We selected these startups for exceptional performance in one of these categories:
- Innovative ideas
- Innovative route to market
- Innovative product
- Exceptional growth
- Exceptional growth strategy
- Societal impact
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Top Therapeutics Startups
Adagio Therapeutics is developing best-in-class antibodies that can broadly neutralize SARS-CoV-2, SARS-CoV-1, and additional potentially emergent coronaviruses. We believe our antibodies will match or exceed the potency and coverage of conventional SARS-CoV-2 antibody programs and can be used as both therapeutic and durable prophylactic treatments.
Our candidates are engineered using best-in-industry antibody discovery capabilities and are designed to maximize potency and duration of effect. Our portfolio includes multiple, non-competing antibodies with distinct binding targets, enabling a strategy that can avoid viral escape..
Sonoma Biotherapeutics is a company invloved the development of adoptive Treg therapies cell for autoimmune and degenerative diseases. Using next generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities.
Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies.. .
Artiva Biotherapeutics is a private biotech company advancing a pipeline of off-the-shelf, allogeneic NK cell therapies, for the treatment of hematologic cancers or solid tumors. Artiva Biotherapeutics was founded on the understanding that NK cells hold enormous therapeutic potential as cancer therapies and the dedication and expertise to overcome technological barriers in the scaling and manufacturing of these cells.
At Artiva, our mission is to deliver highly effective cell therapies that are also safe and immediately available and accessible to any cancer patient who stands to benefit. Artiva’s platform delivers scalability, quality, and cryopreservation to support a pipeline of safe, effective, versatile, and accessible product candidates..
Cellares is revolutionizing cell therapy manufacturing. We are developing a one-of-a-kind solution, The Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are affordable and widely available to patients who can benefit.
The clinical impact of cell therapy in treating cancer has been proven, but this therapeutic approach has several limitations, especially in manufacturing, leaving extremely sick patients waiting for treatment and desperate for hope. Since cell therapy is currently produced for a single patient at a time, it is expensive to manufacture, requiring significant time and resources, and is difficult to scale.
Preclinical and clinical scientists, as well as commercial cell therapy manufacturers also lack the options to fully automate their manufacturing process quickly, safely, cost-effectively and at the scale they need. The Cell Shuttle is an automated and closed end-to-end manufacturing solution that is flexible and scalable, enabling customers to run exact processes specified for their cell therapy.
Compared with the current manual manufacturing processes for cell therapy, the Cell Shuttle’s next-generation automated manufacturing solution has 10 times the scalability (meaning 10 times more patient doses can be produced simultaneously), enables a three-fold reduction in process failure rates and will reduce the per-patient manufacturing cost by up to 70 percent for most processes.. .
Forge Biologics is a gene therapy development engine, focused on enabling access to life-changing gene therapies and helping bring them from an idea into reality. The company partners with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups.
It was founded in 2020 and headquartered in Grove City, Ohio.. .
ANA Therapeutics is a developer of a novel coronavirus vaccine intended to save human lives. It is developing therapeutics to solve the coronavirus pandemic using Niclosamide that enables medical practitioners to treat patients suffering from COVID-19.
It was founded in 2020 and is headquartered in Foster City, California.. .
Federation Bio is pioneering new platforms that target diseases in which the human microbiome can play a curative role. The company’s microbial therapy leverages naturally occurring or engineered bacteria along with a diverse community of supportive bacteria to drive engraftment and durable therapeutic responses.
This approach has potential in a wide range of human conditions, from metabolic disorders and cholestatic diseases to cancer and autoimmune conditions.. .
PostEra uses machine learning to close the design-make-test loop of drug discovery and reduce our clients’ cycle times. We are currently leading an international team of scientists to find a COVID antiviral via on open science initative.
Consider contributing your expertise to the initiative here: https://postera.ai/covid. .
Ophelia offers medication and support for quitting opioids. They are a diverse collection of hearts and minds – doctors, scientists, techies, and citizens – on a mission to offer the best of medicine without the baggage of rehab.
They are driven by science, committed to privacy, and bound to the client’s right to make their own choices. They believe in recommendations, not orders.
It was founded in 2019 and is based in Philadelphia, Pennsylvania.. .
ExeVir Bio is a Belgium-based company that develops single-domain antibody-based therapies that help patients ward off viral infections. The company is harnessing a llama-derived antibody technology platform to generate robust antiviral therapies providing broad protection against coronaviruses.
They using a highly innovative and clinically validated VHH technology to develop treatments for viral infections that may pose a significant global threat. ExeVir Bio develops a rapid response platform for antivirals.
This platform technology enables an agile response to new health threats thanks to its short throughput time to generate drug candidates. The resulting protein-based therapeutics are sufficiently stable and easy to produce at a reasonable cost to enable true global access.
ExeVir Bio was founded in 2020 and is headquartered in Zwijnaarde, Belgium.. .
InnoSkel is a pioneering platform biotechnology company developing therapies for rare skeletal diseases. InnoSkel is developing treatment options for a group of rare skeletal disorders collectively known as type 2 collagenopathies, the most severe of which is Spondyloepiphyseal Dysplasia congenita (SEDc), the second leading cause of dwarfism worldwide.
InnoSkel’s lead gene therapy asset for SEDc has demonstrated good efficacy in proof-of-concept studies. The company’s fundamental mission is to improve the lives of patients living with skeletal dysplasia and to answer their unmet needs, keeping their voices at the heart of all they do.
InnoSkel is a spin-out of the Institut de Biology Valrose at Inserm, the French National Institute of Health and Medical Research, and is based in Nice, France.. .
Immunitas is unlocking human immunology using novel single cell analyses to develop targeted therapeutics for patients with challenging, complex cancers. Translating findings from laboratory research to meaningful clinical advances in humans is a longstanding challenge in the oncology field.
Immunitas was founded to directly address this problem and unlock a variety of novel drug targets based on discovery rooted in human biology. They are pursuing this goal with a team of pioneers in these areas across their scientific founders, management, and investors.
At Immunitas, they employ a single cell sequencing platform to dissect the biology of immune cells in human tumors. Their focus on human samples allows us to start with and stay closer to the most relevant and translatable biology for patients and accelerates the pace of their research.
They are identifying novel, exciting oncology targets and, importantly, developing key biomarkers to guide the selection of patients who may benefit from their new drugs. They are leveraging expertise in antibody discovery and engineering to create powerful therapies that modulate these targets, and are currently advancing a number of programs toward early human studies..
Manifold Bio is a biotechnology company that features a platform that enables multiplexed quantitation of protein therapeutic designs, generating unprecedented data throughout the drug development process to unlock measurement-driven design. The company is building a protein barcoding platform to bring the power of multiplexed measurement to the development of protein therapeutics.
It was founded in 2020 and headquartered in Boston, Massachusetts.. .
Swiftscale Biologics is a healthcare service provider that develops life-saving drugs. Its drugs are designed to improve the lives of the patients.
The company was founded in 2019 and is headquartered in South San Francisco, California.. .
Civetta Therapeutics is a cancer therapeutics company to advance new medicines through small molecule targeting of beta-propeller domains. The company leverages small molecule targeting of beta-propeller domains to develop important therapeutics for cancers and other diseases.
It also develops a broad range of expertise in drugging the propeller domains, spanning from biochemistry to biology to medicinal chemistry Propeller proteins are structural scaffolds that mediate protein-protein interactions of unique substrates. These proteins are found ubiquitously across cell types and can have diverse functional roles in the pathogenesis of cancer, neurodegeneration, metabolic disease, and other areas.
Their vision is to build a portfolio of therapeutics by integrating a broad range of expertise in drugging the propeller domains spanning from biochemistry to biology to medicinal chemistry. These efforts will support the creation of near term therapeutics and longer-term value in becoming a leader in this space.
Civetta Therapeutics was founded in 2019 and is based in Cambridge, Massachusetts, United States.. .
Lassogen is a biotechnology company exploring lasso peptides as a way to develop new medicines. Lassogen was founded in 2019 to unlock the full potential of lasso peptides as a new therapeutic modality for diagnosing and treating some of our most intractable health challenges.
The company is the result of a convergence of technological advances that have opened the door to a vast, new, untapped source of novel medicines.. .
Synendos Therapeutics develops a class of small molecules for the treatment of anxiety and stress-related disorders. The company also develops breakthrough safe and effective therapies for unmet needs in neuropsychiatric disorders through modulation of a new drug target in the endocannabinoid system that enables restoration of the natural functioning of the brain.
The inhibitors act with a new mechanism of action that enables restoration of the natural function of the brain by rebalancing altered neurotransmission in different areas of the bran. There is a high demand for new pharmacological treatments in this area especially for certain diseases such as post-traumatic stress disorder (PTSD) which has a high unmet medical need..
The platform for creating organs and tissues in the lab.They are building a new platform to create organs and tissues in the lab. By combining tissue-specific extracellular matrix proteins as self-assembling hydrogels, they offer the most advanced microenvironment for cell and tissue culture.
Their products are created to allow you to perform state of the art research, from drug discovery to organ fabrication.. .
Asher Bio is an information technology company that specializes in the fields of CFO Office transformation, profitability, and cost management. It focuses on building and developing better immunotherapy for cancer.
The company was founded in 2019 and headquartered in San Francisco, California.. .
Breakpoint Therapeutics is a company that discover and develop new anti-cancer drugs. By targeting the DNA damage response (“DDR”) in cancer cells, Breakpoint Therapeutics aims to advance to clinical development first-in-class oncology drugs that interfere with DNA repair and replication stress tolerance pathways.
Their mission is to develop drugs that succeed and complement PARP inhibitors and facilitate the cure of therapy resistant cancers.. .
Headway is a mental healthcare system provider based in New York. It develops a health insurance advisory platform designed to connect patients with therapists and provides administrative support to therapists who don’t typically accept insurance.
The company was founded by Andrew Adams, Jake Sussman, Dan Ross, and Kevin Chan in 2019.. .
Preventric is a commercial-stage digital health company redefining the way vascular diseases are clinically diagnosed by combining wearable biosensing technology with cloud-based data analytics and machine learning capabilities. The company derives its revenue in the United States.
Its BPro® wearable has been in 20+ clinical trials on 20,000 patients, cited in 70+ peer-reviewed science & medical journals, globally patented, and FDA-cleared for physician use and reimbursement.. .
i2o Therapeutics is a biotech company that develops safe and effective oral formulations of therapies traditionally limited to injections. Using an innovative ionic liquid technology, it leverages the benefits of protecting the drug cargo while also transiently enhancing permeation across the epithelial lining when administered orally.
i2o is focused on creating the next generation of oral peptide and protein-based therapies. The company was founded in 2019 and based in Saratoga, California..
Ochre Bio develops genomic medicines to rejuvenate donors’ livers before transplant, so that everyone who needs a new liver gets one. They use genomics to find and shut down over-active genes driving disease and then go directly to testing therapies in discarded donor livers that keep alive outside of the body.
Ochre Bio is within the heart of Oxford’s biotech innovation hub. Their scientific roots can be traced back to over 15 years leading liver genomics research and experience in bringing advanced therapies to market..
Debut Biotech is a biotechnology company that focuses on providing specialty enzyme solutions combined with continuous manufacturing. It combines the power of enzymes with continuous manufacturing to create and modify small and large molecules for a wide range of industries and applications.
The company was founded in 2019 and is based in San Diego, California.. .
Notitia Biotechnologies develops a biotechnology platform that uses a new method for microbiome data analysis and discovery. The company’s propriety offering, Foundation Guild Microbiome R&D Platform, aims to improve health in patients with unmet medical needs by utilizing microbiome biotherapeutics and allows them to develop unique and effective treatments for various chronic or acute complications.
It was established in Monmouth Junction, New Jersey by Gongze Zhao and Liping Zhao in 2020.. .
Tacalyx develops therapeutics targeting cancer-specific carbohydrate antigens on the surface of metastatic malignant tumors where no satisfactory treatments exist.The name Tacalyx is derived from TACA (Tumor Associated Carbohydrate Antigen) and ‘lyx’ from the term Glycocalyx, the glycan-containing layer covering cells. Cancer cells differ from normal cells by displaying aberrant carbohydrate structures on their surfaces promoting metastasis, angiogenesis or suppression of the immune system.
TACAs result from the aberrant glycosylation that is seen with transformation to a tumor cell and represent attractive targets for cancer treatment since they are displayed with high cancer specificity and enhance tumor virulence via the mentioned diverse mechanisms.. .
Enliven Therapeutics is a precision oncology company developing small molecule therapies to extend and improve patient lives. The company’s discovery process combines clinically validated biological targets and industry-leading chemistry to address the limitations of existing therapies.
This approach allows us to efﬁciently and effectively develop precision oncology therapeutics that enhance overall patient well-being.. .
Nanocan Therapeutics provides medicines and other products intended to patients with certain cancers, respiratory tract infections. The company leverages nanotechnology to create solutions for hard-to-cure indications where current interventions are insufficient.
Through the application of nanotechnology to medicine, Nanocan aims to help improve the quality of life of our patients, increase access to medicine and other treatments, and to reduce global health disparities.. .
Altay Therapeutics is a biotech company focused on finding and discovering small molecule therapies for chronic inflammatory conditions. It is currently focused on finding curative therapies for fibrosis, NASH, and liver cancer.
It develops novel small molecule drugs against transcriptional regulators that are validated drivers of disease. It was founded in 2019 and is headquartered in San Francisco, California..
Pression’s patented, non-invasive, smart compression platform, the Wave, increases circulation body-wide and improves cardiac function. Our initial focus is to support heart failure patients to mobilize excess retained fluids (#1 cause of US hospitalization), increase oxygen delivery to vital organs and improve overall quality of life.
The platform is based on proven science and improves upon nearly all the downsides of previous systems.. .
Enveda Biosciences is a biotechnology company building new medicines from plants. It harnesses the complexity of the natural world to tackle today’s biggest healthcare challenges.
With the help of the advancements in knowledge graphs, machine learning, and metabolomics, they discover the next generation of small molecules. Its technologies systematize the discovery of small molecules and novel targets for complex diseases.
By probing novel chemical space and mechanisms of action, they are breaking the status quo for challenging diseases with a need for effective treatments, such as fibrosis or neurodegeneration. Enveda, launched in 2019, is based in San Francisco, California..
Gyala Therapeutics is focused on developing new CAR-T therapies for treating hematological malignancies. CAR-T (chimeric antigen receptor T cells) is a type of gene therapy in which T lymphocytes -a type of white blood cells that play a key role in immune responses- are extracted from the patient and modified to attack tumour cells.
T lymphocytes are obtained through apheresis (a technique that allows separation of blood components) and genetically reprogrammed with a receptor that binds to a tumor factor. When these cells are transduced back to the patient, they are to specifically recognize tumour cells and attack them.
Several types of CAR-T cells have demonstrated efficacy in the treatment of leukemias and B cell lymphomas.. .
Curamir is a Woburn, MA-based biotechnology company launched and incubated by Delos Capital with an initial academic licensing from SUNY. Through its proprietary miRNA engineering platform and insights into cancer biology, Curamir develops miRNA-based cancer therapeutics with enhanced safety, potency and stability.
Its novel approach addresses current challenges associated with both chemoresistance in cancer and effective systemic delivery of miRNA mimics.. .
Long QT Syndrome (LQTS) is a genetic disorder that causes a prolongation between the beginning of the QRS complex and the end of the T waveQ and T waves on the EKG, indicating a prolongation of ventricular repolarization and the action potential duration. The lengthening of this complex is associated with unexpected and life threatening ventricular arrhythmias.
Click below to learn more about our programs.. .
BIMINI Biotech is a startup that develops innovative therapeutic strategies for oncology. It is developing therapeutic strategies that target the growth hormone receptor (GHR) and its interaction with insulin-like growth factor 1 (IGF-1) for oncology, metabolic diseases, and aging.
The company was founded in 2019 and is based in Leiden, The Netherlands.. .
Pasithea Therapeutics is a biotechnology company that seeks to solve clinical problems such as mental health. The company is led by renowned immunologists based at Stanford University and their academic research is headed by a top psychiatric academic at King’s College London.
The long-term aim is to translate research into clinic-ready drugs. Pasithea Therapeutics’ secondary operations focus on establishing anti-depression clinics across the US and UK, using trained pharmacists to administer intravenous infusions of ketamine.
Pasithea has partnered with two successful clinics for immediate exposure in locations across Los Angeles, New York City, and London.. .
VeraDermics is a dermatology company that creates novel drug delivery mechanisms for a pain-free cure for skin conditions such as warts. It offers a dissolvable microneedle patch solution that administers immunotherapy without any pain, a treatment that stimulates the body’s own immune system to fight off the wart virus.
The patch is applied like a Band-Aid and remains on the skin for less than an hour. During that time, the microneedles, which are composed of the immune-stimulators in a sustained-release polymer matrix, dissolve from the adhesive backing and are implanted into the skin.
The adhesive can then be removed leaving the microneedles to dissolve in the skin over weeks. During that time, immune stimulators are steadily released directly into the wart.
The San Antonio, Texas-located company was founded in 2019 by Lauren Durso, Reid Waldman, Ming Lee, Madeline DeWane, and Kyle Ryder.. .
VAY effortlessly digitizes humans and analyzes movements on a professional level from a simple camera. The computer vision company develops technology to make products smarter, interactive, and more immersive with real-life data and feedback.
VAY offers unique value to their clients with their system and hardware agnostic approach. Applications find themselves in health (e.g., physiotherapy, rehabilitation, or gait/posture analysis), sports, or gaming.
VAY was founded in 2019 and is headquartered in Zurich, Switzerland.. .
The Maine Extraction
The Maine Extraction provides CBD Hemp extraction services and products. Its multi-disciplined principals bring together the expertise and direct, successful hands-on experience in multi-state licenses across botanical therapeutic products, facility construction, security, compliance, cultivation, manufacturing, product development, seed-to-sale tracking and advisory services that have been provided to businesses, associations along with state and federal regulatory bodies.
It was founded in 2019 and is headquartered in Brunswick, Maine.. .
With its platform for medical software, Nia Health is helping to reduce the burden and stigmatization of those affected by chronic skin conditions. The eczema app Nia is the first product of the medical device manufacturer.
Nia’s holistic approach aims to help especially young parents of affected children. Parents should feel more confident in dealing with their child’s disease.
This can be achieved by AI-based clinically validated information. Nia Health’s platform has the potential to compensate existing inefficiencies in the healthcare system, thereby reducing costs..
Matricelf is a biotechnology company that operates 3D print tissues and organs that reducing the risk of implant rejection. The company’s proprietary decellularization process separates stromal cells and extracellular matrix (ECM) from a small omental biopsy sample a, A thermo-responsive hydrogel is produced from the ECM.
The stromal cells are reprogramed into induced pluripotent stem cells (iPSCs) which are then incorporated into the hydrogel before being differentiated into the desired functional tissue using our patent-pending methodology. Matricelf also focuses on spinal cord implants that are produced for patients suffering from intra-abdominal fat biopsy traumatic spinal cord injuries, enabling patients to restore neuronal activity, a motor function that assists them in daily activities, and integrates back into the community.
The company was founded in 2019 by Professor Tal Dvir of the Laboratory for Tissue Engineering and Regenerative Medicine from Tel Aviv University.. .
Aditum Bio is an investment fund that specializes in acquiring and developing pharmaceutical assets. It gives patients access to medicines that may not otherwise be developed.
Aditum Bio was founded on 2019 and is headquartered in San Francisco, California.. .
Mental Health Match
Mental Health Match is a matching tool that offers therapy for those who seek relief, clarity, or healing. Mental Health Match is anonymous and stores nothing that can identify the user.
Users are connected directly to the therapists that are contacted and Mental Health Match does not keep any records of personal data. This tool is best for people who want to quickly find the therapist who best meets their needs, wants to feel a sense of trust, comfort, and connection with a new therapist, and cares about their privacy, security, and confidentiality.
It was founded in 2019 and is headquartered in Sugar Land, Texas.. .
What if we could early detect diseases and monitor health with nothing more than our voice? We are on our mission to unlock the human voice as a prognostic and diagnostic marker for the early-detection of diseases and enable humanity to life a longer and healthier life. EVOCAL Health is developing sophisticated Healthcare Intelligence Algorithms based on Artificial Intelligence and Machine Learning, that uses Vocal Biomarkers like voice-, breathing- and coughing noises to detect diseases.
Vocal Biomarkers have the potential to transform the way we detect and treat diseases through their accuracy, speed and cost-effectiveness. Unlike conventional testing methods, our vision is to use cost-effective everyday technologies like smartphones and enable a broad part of the population to detect and be diagnosed with Vocal Biomarkers on-scale, globally and wherever they are..
Swing is creating the next generation of safe and effective digital therapeutics for people with chronic conditions. Our team of passionate scientists, clinicians, and technologists are partnering with some of the world’s top researchers to develop evidence-based transformative digital treatments.
Swing’s solutions empower patients to regain control of their illnesses. Together, we are helping people achieve improved health so that they can lead more joyful, vibrant lives..
Candlelit Clinic is a digital women’s health company that leverages artificial intelligence to simplify access to culturally relevant and trauma-informed behavioral healthcare for underserved populations of women who are trying to conceive, pregnant and recovering from labor. We help partner healthcare providers and payers offer personalized care management, early intervention and follow-up, self-guided education and counseling 24/7 from any device.
If you’re a BIPOC mom to be, sign up today for early access to our clinic!. .
Epsilen Bio is developing a transformative therapy known as Epigenetic Silencing to treat human diseases. Epsilen Bio’s mission is to develop therapies for patients affected by underserved medical conditions, through stable genomic epigenetic silencing of genes involved in pathological processes.
The company was founded in December 2019 and based in Milan, Italy.. .